Leukocyte Counts of Germ-Free Neonatally Thymectomized CFW Mice

Homograf t Rejection by Neonatally Thymectomized Germ-free Mice1

A response to tissue transplantation was elicited in germ-free neonatally thymectomized CFW and C3H mice by challenge with homotransplantations of methylcholanthrene-inducecl tumor cells and neoplastic lymph node cells. Germ-free thymectomized mice of both CFW and C3H strains accepted all isologous trans plants and rejected all homologous transplants with only 1 excep tion. When these thymectom...

Thymectomized Mice Thymus Grafts in Neonatally Tolerance Induction with

Protection of lethally irradiated mice by spleen cells from neonatally thymectomized mice.

Long-lived, immunologically vigorous (C3H(f) x A(f))F(1) hybrids were produced after lethal irradiation by administration of spleen cells from C3H(f) or syngeneic donors. Further, neonatally thymectomized C3H(f) or A(f) strain donors reconstituted irradiated C3H(f) or (C3H(f) x A(f))F(1) hosts. In addition, C3H(f) spleen cells from nonthymectomized 10- to 15-day-old donors protected irradiated ...

Immunocompetence of Spleen Cells from Neonatally Thymectomized Mice Conferred in Vitro by a Syngeneic Thymus Extract

Impaired immunological competence of spleen cells from neonatally thymectomized C57B1/6 young adult mice was apparent when these cells were tested in an in vitro graft-versus-host assay. Spleen cell inocula prepared from thymectomized mice did not induce enlargement of (C3H/eb x C57BI/6)F(1) newborn spleen explants, whereas the same number of cells from intact donors consistently initiated sple...

Effects of Short-term Epithelial Reticular Cell and Whole Organ Thymus Grafts in Neonatally Thymectomized Mice

Neonatally thymectomized mice were implanted with thymus grafts composed of epithelial reticular cells for periods of 7 and 14 days. Regardless of whether the grafts were placed immediately after thymectomy, or at 3 wk of age, there was little recovery of the lymphocyte depletion and impaired immunologic responsiveness, characteristically found in a neonatally thymectomized host. The findings w...